Vaccine formulations
AssigneeMerial Limited
InventorsAlexis Guy Andre Parisot, Stephanie Marie-Catherine Desgouilles-Blechet, Catherine Charreyre
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Abstract
The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified or weakly purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group comprising an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.
Claims12
A vaccine composition comprising an injectable oil-in-water (O/W) emulsion, comprising:
- (i) an aqueous solution containing at least one immunogen,
- (ii) a paraffin oil,
- (iii) a sorbitan monooleate,
- (iv) an ethoxylated sorbitan trioleate and
- (v) a non-ionic block copolymer.
Dependencies are inferred from the claim text.