Tuberculosis nucleic acids, polypeptides and immunogenic compositions
AssigneeGene Therapy Systems, Inc.
InventorsDavid Roth, Huaping He
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Abstract
The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that may be useful as recombinant, subunit and DNA vaccines. In addition, the invention provides diagnostic kits for Mtb.
Claims21
An isolated Mtb peptide or polypeptide selected from the group consisting of SEQ ID NOS:
- 68, 70, 73, 74, 75, 77, 78, 83, 122, 123, 124, 125, 126, 128, 129, 130, 132, and 133, or an immunogenic fragment thereof.
A recombinant Mtb peptide or polypeptide, wherein the amino terminus of said peptide or polypeptide comprises a HA tag or a His tag, and the carboxy terminus of said peptide or polypeptide is selected from the group consisting of:
- SEQ ID NOS:
- 68, 70, 73, 74, 75, 77, 78, 83, 122 123, 124, 125, 126, 128, 129, 130, 132, and 133.
A recombinant Mtb peptide or polypeptide, wherein the carboxy terminus of said peptide or polypeptide comprises a HA tag or a His tag, and the amino terminus of said peptide or polypeptide is selected from the group consisting of SEQ ID NOS:
- 68, 70, 73, 74, 75, 77, 78, 83, 122, 123, 124, 125, 126, 128, 129, 130, 132 and 133.
A composition comprising at least one isolated Mtb peptide or polypeptide selected from the group consisting of:
- SEQ ID NOS:
- 68, 70, 73, 74, 75, 77, 78, 83, 122, 123, 124, 125, 126, 128, 129, 130, 132, and 133, or an immunogenic fragment thereof, and a pharmaceuticallv acceptable carrier.
Dependencies are inferred from the claim text.