Recombinant lentivirus encoding modified GP 120 signal sequences
AssigneeThe University of Western Ontario
InventorsChil-Yong Kang, Yan Li
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Abstract
Novel HIV vaccines comprising an avirulent and non-cytolytic recombinant HIVs are provided.
Claims13
A recombinant lentivirus having a glycoprotein 120 signal sequence, wherein said glycoprotein 120 signal sequence is selected from the group consisting of the polypeptide sequences listed as SEQ ID NO 3-6, or a functional fragment or variant thereof, wherein said functional fragment or variant thereof contains no more than one (1) positively charged amino acid.
An immunogenic composition comprising a recombinant lentivirus having a glycoprotein 120 signal sequence, wherein said glycoprotein 120 signal sequence is selected from the group consisting of the polypeptide sequences listed as SEQ ID NO 3-6, or a functional fragment or variant thereof, wherein said functional fragment or variant thereof contains no more than one (1) positively charged amino acid.
Dependencies are inferred from the claim text.