Antibodies that bind to pleiotrophin growth factor receptor
AssigneeGeorgetown University
InventorAnton Wellstein
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Abstract
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with that association, the cascade of events associated with pleiotrophin activity can be prevented or reversed. Further, by evaluating the effect of different compounds and conditions on the interaction, new drugs and treatments can be identified for use in preventing certain cancers and growth and developmental disorders.
Claims11
An isolated monoclonal antibody or antibody fragment which binds a pleiotrophin-binding fragment of human Anaplastic Lymphoma Kinase (ALK) and inhibits a pleiotrophin-mediated activity.
A hybridoma which produces a monoclonal antibody that binds a pleiotrophin-binding fragment of human ALK and inhibits a pleiotrophin-mediated activity.
Dependencies are inferred from the claim text.