Replication-competent anti-cancer vectors
AssigneeSaint Louis University
InventorsWilliam S. M. Wold, Karoly Toth, Konstantin Doronin, Ann E. Tollefson
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Abstract
Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
Claims37
A method for treating cancer in an animal having a tumor comprising administering to the tumor an adenovirus vector wherein said adenovirus vector is replication-competent in a normal cell and a tumor cell and overexpresses an adenovirus death protein (ADP), wherein overexpression is defined as overexpression relative to dl309.
Dependencies are inferred from the claim text.