US 7,608,247 B2 · Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation

Abstract

The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.

Claims12

Dependent claims

A method for the treatment of Escherichia coli infection in central nervous system and/or peripheral blood circulation in a mammal, which comprises administering to said mammal an effective amount of an outer membrane protein A (OmpA) of Escherichia coli.

Dependencies are inferred from the claim text.

Facts

Application

12/046,165Filed 11 Mar 2008

Published

US 2009/0233853 A117 Sep 2009

Granted

27 Oct 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

G01N 33/6893
Involving proteins, peptides or amino acids: related to diseases not provided for elsewhere
A61K 38/164
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from bacteria
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
G01N 2800/26
Detection or diagnosis of diseases: infectious diseases, e.g. generalised sepsis

Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation

Life of this patent

Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation

Life of this patent

Abstract

Claims12