Methods of upmodulating adaptive immune response using anti-PD-1 antibodies

A method of upmodulating adaptive immune response comprising:

• contacting a lymphocyte with an isolated anti-PD-1 antibody, wherein the antibody comprises:
• a VH domain or an antigen-binding fragment thereof that comprises 3 CDRs;
• and a VL domain or an antigen-binding fragment thereof that comprises 3 CDRs;
• wherein the antibody comprises at least 3 VH domain CDRs having sequences of:
• SEQ ID NO:23, SEQ ID NO:24 and SEQ ID NO:25;
• or
• SEQ ID NO:29, SEQ ID NO:30 and SEQ ID NO:31;
• or
• SEQ ID NO:35, SEQ ID NO:36 and SEQ ID NO:37;
• or at least 3 VL domain CDRs having sequences of:
• SEQ ID NO:26, SEQ ID NO:27 and SEQ ID NO:28;
• or
• SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34;
• or
• SEQ ID NO:38, SEQ ID NO:39 and SEQ ID NO:40.