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US 7,465,817 B2Granted
Inositolized phospholipids
AssigneeCharite-Universitats Medizin Berlin
InventorsKerstin Danker, Michael Mickeleit, Dieter Mueller, Werner Reutter
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Abstract
The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol backbone, a pharmaceutical composition comprising said phospholipid, a method for preparing said phospholipid and a medicament comprising said phospholipid.
Claims19
A phospholipid according to formula I having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-2 position of the glycerol backbone wherein
- (i) A are independently optionally substituted C1-6 alkyl moieties or two A residues may form an optionally substituted 5- to 10-membered ring,
- (ii) R is a polyhydroxylated aliphatic carbocycle or a derivative thereof being directly or through a linker molecule connected to the oxygen atom of the glycerol backbone,
- (iii) R′ is selected from the group consisting of (i) optionally unsaturated and/or optionally substituted C1-20 alkyl, (ii) optionally unsaturated and/or optionally substituted C2-26 acyl and (iii) hydrogen, and
- (iv) n is an integer ranging from 1 to 5.
1 more element
Dependencies are inferred from the claim text.