Heterocycle derivatives useful as selective androgen receptor modulators (SARMs)

A compound of formula (I)

• wherein
• W is selected from the group consisting of O, S and NRF;
• wherein RF is selected from the group consisting of hydrogen, hydroxy, C1-4alkyl, C1-4alkoxy, cyano and —SO2—C1-4alkyl;
• R1 is selected from the group consisting of C1-4alkyl and halogenated C1-4alkyl;
• R2 is selected from the group consisting of hydrogen, C1-4alkyl, halogenated C1-4alkyl, —C(O)O—C1-4alkyl, —C(O)—C1-4alkyl and —C(O)-(halogenated C1-4alkyl);
• a is an integer from 0 to 1;
• is phenyl;
• R3 is selected from the group consisting of hydrogen, halogen, C1-4alkyl, halogenated C1-4alkyl, cyano, nitro, amino, benzyl, —O-phenyl, —C(O)-phenyl, —S(O)0-2—C1-4alkyl, C1-4alkylamino, di C1-4alkylamino, —O—C1-4alkyl, —NRA—C(O)—C1-4alkyl and —S(O)0-2-phenyl, wherein RA is either hydrogen or C1-4alkyl;
• R4 is selected from the group consisting of hydrogen, halogen, C1-4alkyl, halogenated C1-4alkyl, cyano, nitro, amino, benzyl, —O-phenyl, —C(O)-phenyl, —S(O)0-2—C1-4alkyl, C1-4alkylamino, di C1-4alkylamino, —O—C1-4alkyl, —NRB—C(O)—C1-4alkyl and —S(O)0-2-phenyl, wherein RB is either hydrogen or C1-4alkyl;
• provided that at least one of R3 of R4 other than hydrogen;
• R6 and R7 are each independently selected from the group consisting of hydrogen, halogen, C1-4alkyl, C2-4alkenyl, C1-4alkoxy, cyano, —C(O)O—C1-4alkyl and —S(O)0-2—C1-4alkyl;
• is selected from the group consisting of
• wherein R5′ is selected from the group consisting of halogen and C1-4alkyl;
• and wherein R10 is selected from hydrogen, C1-4alkyl, benzyl or —C(O)—CF3;
• R5 is selected from the group consisting of hydrogen, carboxy, alkyl, halogenated C1-4alkyl, hydroxy substituted C1-4alkyl, cycloalkyl, aryl, aralkyl, —C(O)—C1-4alkyl, —C(O)-(halogenated C1-4alkyl), —C(O)O—C1-4alkyl, —C(O)O-aryl, —C1-4alkyl-S(O)0-2—C1-4alkyl, t-butyl-dimethyl-silyl and trimethylsilyl;
• wherein the aryl, whether alone or as part of a substituent group is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, C1-4alkyl, C1-4alkoxy, halogenated C1-4alkyl, cyano, nitro, —NRC—C(O)—C1-4alkyl, NRC—C(O)-(halogenated C1-4alkyl), —C(O)O—C1-4alkyl, trimethyl-silyl and t-butyl-dimethyl-silyloxy;
• wherein RC and RD are each independently selected from hydrogen or C1-4alkyl;
• or a pharmaceutically acceptable salt thereof.