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US 7,465,803 B2Granted
Nitroderivatives as drugs for diseases having an inflammatory basis
AssigneeNicox S.A.
InventorsPiero Del Soldato, Francesca Benedini, Patrizia Antognazza
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Abstract
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X1-L-(W)p—NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, p is an integer equal to 1 or 0, and L is a covalent bond, CO, oxygen, sulphur, or NR1C where R1C is H or a C1-C5 linear or branched alkyl.
Claims3
A compound having the following general formula (I):
- A-X1-L-(W)p—NO2 (I)
- wherein:
- p is an integer equal to 1 or 0;
- A=R-T1-, wherein
- R has the following formula:
- T1=(CO)t or (X)t′, wherein X=O, S or NR1C, wherein R1C is H or a linear or branched alkyl, having from 1 to 5 carbon atoms, t and t′ are integers and equal to zero or 1, with the proviso that t=1 when t′=0;
- t=0 when t′=1;
- X1=-TB-Y-TB1- wherein
- TB and TB1 are equal or different;
- TB=(CO) when t=0, TB-X when t′=0, X being as above;
- TB1=(CO)tx, or (X)txx, wherein tx and txx have the value of 0 or 1;
- with the proviso that tx=1 when txx=0;
- and tx=0 when txx=1;
- X is as above;
- Y is selected from the following:
- wherein n3 is an integer from 0 to 3 and n3′ is an integer from 1 to 3;
- wherein n3 and n3′ have the above meaning, or
- wherein
- R4 is hydroxy, hydrogen, or R5O— alkoxy wherein R5 is a C1-C10 linear, branched or cyclic alkyl group;
- and
- R2 is a C2-C10 linear or branched alkenylene group which can contain one or more double bonds,
- L=covalent bond, CO or X, X being as defined above;
- W=YTO wherein YT has the same meanings of Y as defined above, and YT is equal to or different from Y.
20 more elements
Dependencies are inferred from the claim text.