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US 7,465,753 B2Granted
Glycoside-containing liposome
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsShin Yazawa, Izumi Takai, Touyou Nishimura
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Abstract
A drug product which can maximize the effect of a cholestanol glycoside useful as an anticancer agent. The present invention provides a liposomal composition containing a glycoside exhibiting antitumor activity, a phospholipid, and a positive-charge-providing substance; the glycoside being composed of GlcNAc-Gal-, GlcNAc-Gal-Glc-, Fuc-Gal-, Gal-Glc-, or Gal- as a sugar moiety, and a hydrophobic compound capable of forming a liposome.
Claims8
A liposomal composition comprising:
- a glycoside exhibiting antitumor activity, wherein said glycoside is represented by a compound of formula (1):
- a phospholipid;
- and
- a positive-charge-providing aliphatic amine selected from the group consisting of stearylamine and oleylamine,
- wherein G represents a sugar moiety selected from the group consisting of GlcNAcβ1,4Gal- and Fucα1,3Gal-, and
- wherein said phospholipid and said positive-charge-providing aliphatic amine are capable of forming a liposome.
3 more elements
Dependencies are inferred from the claim text.