US 7,465,750 B2 · Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods

Abstract

This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.

Claims16

Dependent claims

A compound having the structure:

wherein B is phenyl and the phenyl is optionally substituted with one or more of the following:
—F, —Cl, —Br, —CF3, straight chained or branched C1-C7 alkyl, C3-C7 cycloalkyl, —N(R4)2, —OR4, —COR4, —NHCOR4, —CO2R4, or —CON(R4)2;
wherein each R4 is independently —H, straight chained or branched C1-C7 alkyl, —CF3, or phenyl;
wherein A is heteroaryl, where the heteroaryl is furanyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, and triazinyl;
wherein the heteroaryl may be substituted with one or more of the following:
—F, —Cl, —Br, —I, —NO2, —CN, straight chained or branched C1-C7 alkyl, straight chained or branched C1-C7 monofluoroalkyl or polyfluoroalkyl;
wherein each of Y1, Y2, Y3, and Y4 is independently —H;
straight chained or branched C1-C7 alkyl, —CF3, —F, —Cl, —Br, —I, —OR4, —N(R4)2, or —CON(R4)2;
or
a pharmaceutically acceptable salt thereof.

7 more elements

Dependencies are inferred from the claim text.

Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods

Life of this patent

Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods

Life of this patent

Abstract

Claims16