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US 7,465,745 B2Granted
Cathepsin S inhibitors
AssigneeBoehringer Ingelheim Pharmaceuticals, Inc.
InventorsEugene R. Hickey, Wiemen Liu, Sanxing Sun, Yancey David Ward, Erick Richard Roush Young
Life of this patent
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Abstract
This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates to processes for preparing such compounds and pharmaceutical compositions comprising them.
Claims4
A compound of the formula (I) or (II):
- wherein X in each case is chosen from
- R1 is:
- or the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.