Compounds and their use in therapy

A compound corresponding to formula (I)

• wherein
• X is S, SO or SO2
• R1 and R2 are individually selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloheteroalkyl, substituted cycloheteroalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, cycloheteroalkyl-alkyl, and substituted cycloheteroalkyl-alkyl,
• whereby the cycloheteroalkyl moiety of cycloheteroalkyl-alkyl and substituted cycloheteroalkyl-alkyl is a four- to eight-membered heterocyclic ring containing at least one heteroatom selected from N, O and 5, the number of N atoms being 0-3 and the number of O and S atoms each being 0-1, which ring may be saturated, partly unsaturated or hydroaromatic;
• whereby the cycloheteroalkyl moiety is optionally substituted by up to three substituents independently selected from the group consisting of oxo, alkyl, aryl or aryl-(C1-C4)-alkyl both optionally substituted in the aryl moiety, hydroxyl, (C1-C6)alkoxy, halogenated (C1-C6)alkyl, halogenated (C1-C6)alkoxy, carboxyl-(C1-C6)alkyl, thiol, nitrile, sulfamoyl, sulfonamide, carboxyl, aryloxy or arylalkyloxy both optionally substituted in the aryl moiety, (C1-C6)alkylthio, arylthio or arylalkylthio both optionally substituted in the aryl moiety, amino, amido, acyl, and acylamino;
• or R2 itself may be independently selected from acyl, carboxyl, or amido,
• wherein R1 and R2 cannot be simultaneously unsubstituted alkyl, and
• wherein if R3, R5 and R6 all simultaneously represent hydrogen and R4 represents hydrogen or methyl, then R2 is different from methyl;
• R3 and R 4 are individually selected from the group consisting of hydrogen, oxo, halogen or dihalogen, acyl, alkyl, substituted alkyl, hydroxyl, carboxyl, amido, amino, nitrile, thio, alkoxy, acyloxy, aryloxy, alkylthio and arylthio;
• R5 and R6 are individually selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, hydroxyl, alkoxy, aryloxy, and carboxyl;
• the hydrocarbon chain —C(R3)-C(R4)-C(R5)-C(R6)- of the six-membered ring is saturated or contains one or two double bonds between the carbon atoms;
• and wherein if all the substituents R3, R4, R5 and R6 are simultaneously hydrogen, then the six-membered ring comprising the hydrocarbon chain —C(R3)-C(R4)-C(R5)-C(R6)- is an aromatic ring.

A compound corresponding to formula (I)

• wherein
• X is S, SO or SO2
• R1 and R2 are individually selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloheteroalkyl, substituted cycloheteroalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, cycloheteroalkyl-alkyl, substituted cycloheteroalkyl-alkyl,
• whereby the cycloheteroalkyl moiety of cycloheteroalkyl-alkyl and substituted cycloheteroalkyl-alkyl is a four- to eight-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the number of N atoms being 0-3 and the number of O and S atoms each being 0-1, which ring may be saturated, partly unsaturated or hydroaromatic;
• whereby the cycloheteroalkyl moiety is optionally substituted by up to three substituents independently selected from the group consisting of oxo, alkyl, aryl or aryl-(C1-C4)-alkyl both optionally substituted in the aryl moiety, hydroxyl, (C1-C6)alkoxy, halogenated (C1-C6)alkyl, halogenated (C1-C6)alkoxy, carboxyl (C1-C6)alkyl, thiol, nitrile, sulfamoyl, sulfonamide, carboxyl, aryloxy or arylalkyloxy both optionally substituted in the aryl moiety, (C1-C6)alkylthio, arylthio or arylalkylthio both optionally substituted in the aryl moiety, amino, amido, acyl, and acylamino;
• or R2 itself may be independently selected from acyl, carboxyl, or amido,
• wherein R1 and R2 cannot be simultaneously unsubstituted alkyl, and
• wherein if R3, R5 and R6 all simultaneously represent hydrogen and R4 represents hydrogen or methyl, then R2 is different from methyl;
• R3 and R 4 are individually selected from the group consisting of hydrogen, oxo, halogen or dihalogen, acyl, alkyl, substituted alkyl, hydroxyl, carboxyl, amido, amino, nitrile, thio, alkoxy, acyloxy, aryloxy, alkylthio and arylthio;
• R5 and R6 are individually selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, hydroxyl, alkoxy, aryloxy, or carboxyl,
• the hydrocarbon chain —C(R3)-C(R4)-C(R5)-C(R6)- of the six-membered ring is saturated or contains one or two double bonds between the carbon atoms;
• wherein if R3, R4, R5 and R6 are all simultaneously hydrogen, then the six membered ring comprising the hydrocarbon chain —C(R3)-C(R4)-C(R5)-C(R6)- is an aromatic ring;
• provided that said compound is not (3-Benzyl-7-tert-butyl-4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidin-2-yl)-acetic acid methyl ester or 2,3-Dibenzyl-7-tert-butyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one.