Substituted pyrrolo[2.3-B]pyridines

A compound represented by Formula I:

• a pharmaceutically acceptable salt thereof, wherein
• X is C—CN;
• Cy is
• Z is hetaryl, —C1-6alkyl-O—C1-6alkyl-, —C0-6alkyl-(heterocyclyl), —C0-6alkyl-(hetaryl), —C(O)—C0-6alkyl, —C(O)—C0-6alkyl-O—C0-6alkyl, —C(O)—C0-6alkyl-O—C1-6alkyl-O—C0-6alkyl, —C(O)—C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-(heterocyclyl), —C(O)—C0-6alkyl-(heterocyclyl)-C(O)—C0-6alkyl, —C(O)—C0-6alkyl-(hetaryl), —S(O)2—C0-6alkyl, —S(O)2—N(C0-6alkyl)(C0-6alkyl), or —S(O)2—(hetaryl), wherein any of the alkyl, heterocyclyl, or hetaryl optionally is substituted with 1-6 independent halo, OH, —C0-6alkyl-O—C0-6alkyl, —C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-(heterocyclyl), or —C0-6alkyl;
• or z is
• in which the wavy bond is the point of attachment, and wherein the piperazine or morpholine moieties are optionally substituted with 1-6 independent C0-6alkyl groups;
• Y is —C(C0-6alkyl)(C0-6alkyl)-, —N(C0-6alkyl)-, —N(C0-6alkyl)-C1-6alkyl-, O, S, >N—C2-6alkyl-N—(C0-6alkyl)(C0-6alkyl), >N—C2-6alkyl-O—C0-6alkyl, >N—C1-6alkyl-C(O)—NH—C0-6alkyl, or >N—C2-6alkyl-N—C(O)—C1-6alkyl;
• wherein R1 is selected from the following table:

A compound represented by Formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• X is C—CN;
• Cy is
• Y is —C(C0-6alkyl)(C0-6alkyl)-, —N(C0-6alkyl)-, —N(C0-6alkyl)-C1-6alkyl-, O, S, >N—C2-6alkyl-N—(C0-6alkyl)(C0-6alkyl), >N—C2-6alkyl-O—C0-6alkyl, >N—C1-6alkyl-C(O)—NH—C0-6alkyl, or >N—C2-6alkyl-N—C(O)—C1-6alkyl;
• and
• R1 is aryl, hetaryl, or heterocyclyl, optionally substituted with 1-6 independent halo, —CN, —OH, —C0-6alkyl, —C3-10cycloalkyl, -haloC1-6alkyl, —C2-6alkynyl, —N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-(heterocyclyl), —C1-6alkyl-C(O)—C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —O—C0-6alkyl-(heterocyclyl), —C0-6alkyl-O—C0-6alkyl, —C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —O—C0-6alkyl-(hetaryl), —S(O)2—N(C0-6alkyl)(C0-6alkyl), aryl, hetaryl, or heterocyclyl substituents, or substituted with an oxo (═O) using a bond from the aryl, hetaryl, or heterocyclyl ring, wherein any of the substituents optionally is substituted with 1-6 independent halo, CN, OH, —C0-6alkyl-O—C0-6alkyl, —C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-N(C0-6alkyl)(C0-6alkyl), —C(O)—C0-6alkyl-(heterocyclyl), or C0-6alkyl;
• wherein z is selected from the following table: