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AssigneeKissei Pharmaceutical Co., Ltd.
InventorsHideki Fujikura, Nobuhiko Fushimi, Toshihiro Nishimura, Takeshi Nakabayashi, Masayuki Isaji
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The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
A method for the treatment of a disease associated with hyperglycemia, which comprises administering to a patient in need thereof an effective amount of a glucopyranosyloxypyrazole derivative of the following general formula or a pharmaceutically acceptable salt thereof:
A method for increasing the amount of urinary glucose excretion, which comprises administering to a subject in need thereof an amount of a glucopyranosyloxypyrazole derivative of the following general formula, or a pharmaceutically acceptable salt thereof, effective to increase the amount of urinary glucose excretion in the subject:
A method for lowering blood glucose concentration, which comprises administering to a subject in need thereof an amount of a glucopyranosyloxypyrazole derivative of the following general formula, or a pharmaceutically acceptable salt thereof, effective to lower blood glucose concentration in the subject:
Dependencies are inferred from the claim text.