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US 7,465,709 B2Granted
Structural formulas based on the repetitive motifs of salivary proline rich proteins mucin and collagen designed to modulate cell and tissue growth division and differentiation
OwnerZlatko Ademovic, Nikola Stambuk +2inventors
InventorsZlatko Ademovic, Nikola Stambuk, Pasko Konjevoda, Darko Mikus
Life of this patent
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Abstract
Computational analysis was used to derive structural peptide formulas SALIVAR, SALIVAL, SALIVAN characterizing common repetitive fragments that reconstruct a large number of salivary proline rich proteins. Short repetitive sequences and variants of the mucin (MUKOSEPT) and collagen (PROCOL α) have been also derived. The purpose of the derived sequences is the modulation of cell and tissue growth, division and differentiation.
Claims14
A pharmaceutical composition comprising at least one polypeptide, wherein the polypeptide consists of SEQ ID NO:
- 5 and the amino acid at the first position of SEQ ID NO:
- 5 is selected from the group consisting of asparagine, aspartate, glutamate, glutamine, arginine, serine, lysine, threonine, or alanine.
Dependencies are inferred from the claim text.