Oral detection test for cannabinoid use
AssigneeLabOne, Inc.
InventorsDavid Day, David J. Kuntz, Michael S. Feldman
Life of this patent
Estimating the term…
Abstract
A method for confirming the active intake of marijuana and its active component Δ9-tetrahydrocannabinol (“Δ9-THC”) by detecting the amount of 11-nor-Δ9-THC carboxylic acid (“THCA”) in oral fluid at the picogram per milliliter (pg/ml) level using chromatography/mass spectrometry/mass spectrometry (“GC/MS/MS”).
Claims60
A method for confirming the active intake of marijuana in a test subject comprising the steps of:
- obtaining a test sample of oral fluid from said test subject;
- and
- detecting the amount of 11-nor-Δ9 THC carboxylic acid (“THCA”) in said test sample,
- wherein said THCA has not been externally added to said test sample and said amount of THCA is less than about 240 pg/ml but greater than a predetermined cutoff amount;
- wherein the presence of THCA in said test sample in an amount greater than said predetermined cutoff amount confirms the active intake of marijuana by said test subject.
A method for testing whether a test subject has falsely tested negative for the active intake of marijuana comprising the steps of:
- obtaining a test sample of oral fluid from said test subject who has tested negative for active marijuana intake;
- and
- detecting the amount of 11-nor-Δ9 THC carboxylic acid (“THCA”) in said oral fluid in said test sample, wherein said THCA has not been externally added to said test sample and said amount of THCA is less than about 240 pg/ml but greater than a predetermined cutoff amount;
- wherein the presence of THCA in said test sample in an amount greater than said predetermined cutoff amount indicates the active intake of marijuana by said test subject.
A method for determining active intake of marijuana by a subject, comprising:
- (i) detecting by an assay an amount of 11-nor-Δ9 THC carboxylic acid (“THCA”) in an oral fluid sample from said subject, wherein said assay is capable of detecting THCA in the pg/ml range;
- and
- (ii) comparing said detected amount of THCA with a cutoff value wherein said cutoff value is a value between about 10 pg/ml and about 30 pg/ml,
- wherein when said amount of THCA detected is higher than said cutoff value, active intake of marijuana by said subject is indicated.
A method for determining active intake of marijuana by a subject, comprising:
- (i) detecting by an assay an amount of 11-nor-Δ9 THC carboxylic acid (“THCA”) in an oral fluid sample from said subject, wherein said assay is capable of detecting THCA in the pg/ml range;
- and
- (ii) comparing said detected amount of THCA with a control amount of THCA in a control sample of oral fluid from a control subject, who has not actively consumed marijuana, wherein when said amount of THCA detected is higher than said control amount of THCA by a preset differential of between about 10 pg/ml and about 240 pg/ml, active intake of marijuana by said subject is indicated.
A method for determining whether a subject has falsely tested negative for active intake of marijuana, comprising:
- (i) detecting by an assay an amount of 11-nor-Δ9 THC carboxylic acid (“THCA”) in an oral fluid sample from said subject, wherein said assay is capable of detecting THCA in the pg/ml range;
- and
- (ii) comparing said detected amount of THCA with a control amount of THCA in a control sample of oral fluid from a control subject, who has not actively consumed marijuana, wherein when said detected amount of THCA is higher than said control amount of THCA by a preset differential of between about 10 pg/ml and about 240 pg/ml said subject falsely tested negative for active intake of marijuana is indicated.
A method for determining active intake of marijuana by a subject, comprising:
- (i) detecting a specified amount of 11-nor-Δ9 THC carboxylic acid (“THCA”) in an oral fluid sample from said subject by mass spectrometry, and
- (ii) comparing said detected amount of THCA with a cutoff value wherein said cutoff value is a value between about 10 pg/ml and about 30 pg/ml,
- wherein when said amount of THCA detected is higher than said cutoff value, active intake of marijuana by said subject is indicated;
- and wherein said mass spectrometry is capable of detecting the amount of THCA in said sample in the pg/ml range.
Dependencies are inferred from the claim text.