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US 7,465,585 B1Granted
Compositions and methods for inhibiting cell migration
AssigneeThe Burnham Institute
InventorsMark Mercola, Ruchika Gupta
Life of this patent
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AssigneeThe Burnham Institute
InventorsMark Mercola, Ruchika Gupta
Estimating the term…
The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention.
A method of mobilizing cells comprising contacting the cells with an effective amount of a fragment of Dickkopf-1 (Dkk1) protein of the formula:
A method of mobilizing cells comprising contacting the cells with an effective amount of human Dickkopf-1 (Dkk1) protein set forth as SEQ ID NO:5 comprising a mutation in the amino terminal cysteine rich domain (CRD) and a mutation in the carboxy-terminal CRD.
Dependencies are inferred from the claim text.