Recombinant RSV virus expression systems and vaccines
AssigneeMedImmune, LLC
InventorsHong Jin, Roderick Tang, Shengqiang Li, Martin Bryant
Life of this patent
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Abstract
The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
Claims8
An isolated infectious Respiratory Syncytial Viral (RSV) particle which comprises an RSV antigenome or genome comprising (i) at least one functional deletion in the M2-2 open reading frame, and (ii) encoding one or more amino acid exchanges in the L protein at the following positions 135, 136, 146, 147, 148, 157, 158, 255, 256, 510, 511, 520, 568, 569, 587, 588, 1025, 1026, 1033, 1034, 1187, 1188, 1189, 1190, 1208, 1209, 1306, 1307, 1378, 1379, 1663, 1725, 1726, 1957, 1958, 2043, and 2044.
Dependencies are inferred from the claim text.