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US 7,465,550 B2Granted
Method for screening taste-modulating compounds
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
InventorsCharles S. Zuker, Jon Elliot Adler, Nicholas J.P. Ryba, Ken Mueller, Mark Hoon
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Abstract
The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
Claims23
A method for identifying a compound that modulates taste signaling in taste cells, the method comprising the steps of:
- (i) contacting a taste transduction G protein-coupled receptor polypeptide with the compound, the polypeptide comprising greater than 90% amino acid sequence identity to SEQ ID NO:7 and binding a bitter tastant;
- and
- (ii) determining the functional effect of the compound upon the polypeptide, thereby identifying a compound that modulates taste signaling in taste cells.
Dependencies are inferred from the claim text.