Methods of preventing or treating graft versus host reaction by administering an antibody or portion thereof that binds to AILIM
AssigneeJapan Tobacco Inc.
InventorsKatsunari Tezuka, Yoshihiro Watanabe, Ryo Abe
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Abstract
An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and osteoarthritis, graft versus host disease, graft immune rejection, inflammation (hepatitis and inflammatory bowel diseases), diseased condition accompanied by the excessive production of an antibody against a foreign antigen triggered by immunological sensitization by the antigen.
Claims4
A method of preventing or treating graft versus host reaction in a subject, the method comprising administering to the subject an effective amount of a composition comprising (a) an antibody or a portion thereof that binds to human AILIM and inhibits proliferation of an AILIM-expressing cell or production of interferon-gamma or interleukin-4 by an AILIM-expressing cell, and (b) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.