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US 7,465,434 B2Granted
Diagnosis of blood clots using fibrin-binding proteins bound with contrast agents
OwnerJacob Benfordinventor
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Abstract
This invention describes how to modify a fibrin-binding protein, such as tPA, with a contrast agent, such as iodine. This substance could then be given to a patient suspected of having a blood clot by an intravenous route, and then detected by a radiographic study at a short pre-determined time later. Appropriate therapy is started immediately as determined by the radiographic study.
Claims15
A method for detecting a blood clot in a mammalian patient, the method comprising:
- (a) using a nucleic acid sequence to express a fibrin-binding protein wherein the sequence has been modified to delete a coding sequence that codes for the serine protease domain to remove fibrinolytic activating properties of the fibrin-binding protein;
- (b) producing a compound comprising the fibrin-binding protein and a contrast agent;
- (c) introducing the compound into the patient via bolus by an intravenous or intra-arterial insertion;
- (d) binding the compound to a blood clot;
- and
- (e) detecting the compound bound to the blood clot using a radiographic study.
3 more elements
A method for detecting a blood clot in a mammalian patient, the method comprising:
- (a) using a nucleic acid to express a fibrin-binding protein wherein a sequence of the nucleic acid has been modified to delete a coding sequence that codes for the serine protease domain to remove fibrinolytic activating properties of the fibrin-binding protein;
- (b) producing a compound comprising the fibrin-binding protein and a contrast agent;
- (c) introducing the compound into the patient via bolus by an intravenous or intra-arterial insertion;
- (d) binding the compound to a blood clot;
- and
- (e) detecting the compound bound to the blood clot using a radiographic study.
3 more elements
Dependencies are inferred from the claim text.