Back to results
US 7,411,089 B2Granted
Nateglinide crystals
AssigneeAjinomoto Co., Inc.
InventorsYoshihito Koguchi, Tomoko Nakao, Michito Sumikawa
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeAjinomoto Co., Inc.
InventorsYoshihito Koguchi, Tomoko Nakao, Michito Sumikawa
Estimating the term…
New nateglinide crystals, i.e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4°, 5.2°, 15.7°, 18.5°(2θ)), M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8°(2θ)) and P-type crystals (main peaks in powder X-ray diffraction: 4.8°, 5.3°, 14.3°, 15.2°(2θ)), can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble or, alternatively, by dissolving nateglinide in a mixed solvent composed of a solvent in which nateglinide is highly soluble and another solvent in which it is difficultly soluble, cooling the nateglinide solution to form crystals, filtering the mixture and drying the crystals at a specified temperature.
Nateglinide A-type crystals having the following powder X-ray diffraction peaks:
A method for producing nateglinide A-type crystals, which comprises dissolving nateglinide in a mixed solvent composed of a solvent in which nateglinide is highly soluble and another solvent in which it is difficultly soluble at room temperature or with heating, cooling the nateglinide solution to a temperature of below 10° C. to form crystals, filtering the mixture and drying the obtained crystals at 30° C. to 80° C.
Dependencies are inferred from the claim text.