Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
AssigneeBristol-Myers Squibb Company
InventorsBingwei V. Yang, Lidia M. Doweyko, Arthur M. Doweyko
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Abstract
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I): where X is S, O or N; Z is —T—COOR1 or —T—COR1; and T, R, R1, Ra, Rb, Rc, Rd, Z, A and B are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
Claims7
A compound having the structure:
- or an stereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein
- X is S;
- A1 is a bond or methylene;
- R is H, CH3, or C2H5;
- R1 is selected from alkyl and aryl;
- and
- Rb is CN, NO2, Cl, or Br.
A compound selected from:
- (ii) a stereoisomer or pharmaceutically acceptable salt of (i), thereof.
Dependencies are inferred from the claim text.