Attractin/mahogany-like polypeptides, polynucleotides, antibodies and methods of use thereof
AssigneeImmunex Corporation
InventorDirk M. Anderson
Life of this patent
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Abstract
The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides or fragments, and assays and methods employing these polypeptides, antibodies, and polynucleotides.
Claims12
An isolated nucleic acid molecule comprising a polynucleotide encoding a polypeptide consisting of the sequence as set forth in SEQ ID NO:2.
An isolated nucleic acid molecule comprising a polynucleotide consisting of a sequence selected from the group consisting of:
- a) SEQ ID NO:1;
- b) SEQ ID NO:1, wherein T can also be U;
- and
- c) the full complementary sequence of SEQ ID NO:1 or.
An isolated polynucleotide consisting of a sequence selected from the group consisting of:
- a) SEQ ID NO:1 from about nucleotide 181 to 4137;
- b) SEQ ID NO:1 from about nucleotide 181 to 3690;
- c) the full complementary sequence of a) or b);
- and
- d) any of a), or b), wherein T can also be U.
An isolated nucleic acid molecule comprising a polynucleotide encoding a polypeptide consisting of SEQ ID NO:
- 2 with one amino acid substitution selected from the group consisting of:
- Asp at position 46, Gly at position 134, Tyr at position 405, Leu at position 415, Arg at position 445, Ala at position 473, Ile at position 593, Ser at position 695, Arg at position 759, Pro at position 837, Ala at position 935, Ile at position 948, Phe at position 982, Arg at position 1002, Lys at position 1005, Arg at position 1076, Arg at position 1088, Gly at position 1125, Cys at position 1126, Pro at position 1175, Arg at position 1218, Arg at position 1240, Ala at position 1293, and Gly at position 1294, wherein the polypeptide is capable of inducing monocyte or macrophage activation.
Dependencies are inferred from the claim text.