Monoclonal blocking antibody to human RANKL
AssigneeImmunex Corporation
InventorDirk M. Anderson
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Abstract
Disclosed herein are kits for detecting RANKL protein or nucleic acids, the kits comprising isolated human RANKL polypeptides, RANKL nucleic acids and/or antibodies specific for RANKL.
Claims4
An isolated blocking antibody that binds to a human RANKL polypeptide as set forth in SEQ ID NO:13 and inhibits the binding of the human RANKL polypeptide to a human RANK polypeptide as shown in SEQ ID NO:6.
An isolated blocking antibody that binds to a fragment of a human RANKL polypeptide as shown in SEQ ID NO:13 and inhibits the binding of the human RANKL polypeptide to a human RANK polypeptide as shown in SEQ ID NO:6, wherein the fragment is selected from the group consisting of
- a) an extracellular domain comprising amino acids 69-317 of SEQ ID NO:13, and
- b) a receptor binding domain comprising amino acids 162-317 of SEQ ID NO:13.
Dependencies are inferred from the claim text.