Slo4 potassium channel proteins
AssigneeIcagen, Inc.
InventorsTimothy James Jegla, Julie Dickson Witzel
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.
Claims8
An isolated Slo4 polypeptide comprising an alpha subunit of a Slo potassium channel, the polypeptide:
- (i) forming, with at least one additional alpha subunit, a potassium channel comprising the characteristic of voltage-gating;
- and
- (ii) comprising an amino acid sequence having at least 80% identity to SEQ ID NO:4.
Dependencies are inferred from the claim text.