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US 7,411,004 B2Granted
Sulphones which modulate the action of gamma secretase
AssigneeMerck Sharp & Dohme Corp.
InventorsTimothy Harrison, Paul Joseph Oakley, Martin Richard Teall
Life of this patent
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Abstract
Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
Claims1
A compound of formula I
- wherein
- Ar1 is selected from 4-chlorophenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 3,4-difluorophenyl, 3,4-dichlorophenyl and 4-methoxyphenyl;
- Ar2 is selected from 2,5-dichlorophenyl, 2,5-difluorophenyl and 2-hydroxymethyl-5-fluorophenyl;
- R1 represents H, or C1-6alkyl or C2-6alkenyl, any of which is optionally substituted by halogen, CN, NO2, CF3OH, C1-4alkoxy or C1-4alkoxycarbonyl;
- R2 represents a saturated or unsaturated hydrocarbon linking group of up to 6 carbon atoms;
- X represents —O—, —S—, —SO2—, —N(R4)—, —C(O)—, —OC(O)—, —C(O)O—, —C(O)N(R4)—, —N(R4)C(O)—, —OC(O)O—, —N(R4)C(O)O—, —OC(O)N(R4)—, —SO2N(R4)— or —N(R4)SO2—;
- R3 represents C1-10alkyl, C2-6alkenyl or C2-6alkynyl, any of which may be substituted by OR4;
- R4 represents H or C1-4alkyl
- m and n are each 0;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.