Inhibition of Hepatitis B virus by cyclohexenone compounds from Antrodia camphorata
AssigneeGolden Biotechnology Corporation
InventorsSheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
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Abstract
The present invention relates to a compound of Antrodia camphorata used to inhibit HBV, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata, and its use in inhibiting HBV effectively. The cyclohexenone compound according to the present invention showed cytotoxicity on HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles, further inhibited synthesis of HbsAg and HbeAg effectively to achieve the goal of HBV inhibition.
Claims12
A method for the treatment of HBV-induced diseases which comprises administering to a subject in need thereof an effective amount of a cyclohexenone compound of Antrodia camphorata having the following formula:
- wherein X and Y is oxygen or sulfur, R1, R2 and R3 are each a hydrogen atom, methyl or (CH2)m—CH3, and m=1-12;
- n=1-12.
Dependencies are inferred from the claim text.