Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection

A method of treating hepatitis C infection in a subject in need of such treatment, comprising administering to the subject a compound selected from the group consisting of Formula V and Formula VI:

• wherein:
• X1 is selected from the group consisting of O, S and NR9, wherein R9 is H or alkyl;
• X2 is CH or N;
• A is selected from the group consisting of H, alkyl,
• R1, R2, R3, and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, alkyihalide, amidine, nitro and amino groups;
• R6 is H, alkyl or aryl;
• and
• R7 and R8 are each independently selected from the group consisting of H and alkyl;
• or a pharmaceutically acceptable salt thereof, in an amount sufficient to treat the hepatitis C infection.

A method of treating a culture for bovine viral diarrhea virus (BVDV) infection, comprising administering to the culture a compound selected from the group consisting of Formula (V)-Formula (VI):

• wherein:
• X1 is selected from the group consisting of O, S and NR9, wherein R9 is H or alkyl;
• X2 is CH or N;
• A is selected from the group consisting of H, alkyl, aryl,
• R1, R2, R3, and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, amidine, halide, alkylhalide, nitro and amino groups;
• R6 is H, alkyl or aryl;
• and
• R7 and R8 are each independently selected from the group consisting of H and alkyl;
• or a pharmaceutically acceptable salt thereof, in an amount sufficient to treat the BVDV infection.

A method of treating bovine viral diarrhea virus (BVDV) in a culture medium surrounding an in vitro-produced embryo, comprising administering to the culture medium a compound selected from the group consisting of Formula (V)-Formula (VI):

• wherein:
• X1 is selected from the group consisting of O, S and NR9, wherein R9 is H or alkyl;
• X2 is CH or N;
• A is selected from the group consisting of H, alkyl, aryl,
• R1, R2, R3, and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, amidine, halide, alkylhalide, nitro and amino groups;
• R6 is H, alkyl or aryl;
• and
• R7 and R8 are each independently selected from the group consisting of H and alkyl;
• or a pharmaceutically acceptable salt thereof, in an amount sufficient to treat the BVDV.