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US 7,410,994 B2Granted
Indole derivatives as anti-inflammatory agents
AssigneeRoche Palo Alto LLC
InventorsChris Allen Broka, Jeffrey Allen Campbell
Life of this patent
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Abstract
This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents
Claims8
A compound selected from the group of compounds represented by Formula I
- wherein:
- A is —CH2—, or —O—;
- Ar is an optionally substituted phenyl;
- R1 is hydrogen, alkyl, alkoxy, hydroxy, hydroxyalkyl, alkylthio, halo, cyano, —C(O)NR5R6, —NR5R6, —(CR′R″)0-3OC(O)R5, —(CR′R″)0-3SO2R5, and —(CR′R″)0-3NSO2R5, wherein R5, R6, R′ and R″ are each independently in each occurrence hydrogen or alkyl, with the proviso that when A is —CH2—, then R1 is not —C(O)NR5R6;
- R2 is hydrogen, alkyl, alkoxy, hydroxy, halo, haloalkyl, nitro, cyano, or —NR5R6, wherein R5 and R6 are as defined previously;
- R3 is —SOR7, —SO2R7, or —SO2NR5R6 wherein R7 is alkyl, hydroxyalkyl, alkoxyalkyl, or alkoxycarbonylalkyl;
- and R5 and R6 are as defined previously;
- R4 is hydrogen or alkyl;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.