2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof

A compound of Formula IV:

• and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, and mixtures thereof, wherein
• Ar is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• Q is selected from cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• R1 and R2 are independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• or R1 and R2 together with the nitrogen to which R1 and R2 are attached form a ring chosen from cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, and substituted heteroaryl;
• p is selected from 2, 3, 4, and 5;
• and
• q is 0 or 1.