Compounds

A compound according of formula (Ia), a carboxylic acid ester or a pharmaceutically acceptable salt thereof:

• wherein:
• R1, R2 and R3 are independently C1-6alkyl, halogen, C1-6alkoxy, hydroxy, cyano, CF3, nitro, C1-6alkylthio, amino, mono- or di-C1-6alkylamino, carboxy, C1-6alkanoyl, amido, mono- or di-C1-6alkylamido, NHCOR9 or NHSO2R9 in which R9 is C1-6alkyl, C3-7cycloalkyl or phenyl (optionally substituted by up to three groups selected from C1-6alkyl, halogen, C1-6alkoxy, cyano, phenyl or CF3) or is a group -E-(CH2)1-6NRxRy in which B is a single bond or —OCH2— and Rx and Ry are independently hydrogen, C1-6alkyl or combine together to form a 5-7 membered heterocyclic ring;
• R4 is hydrogen, C1-6alkyl, halogen or C1-6alkoxy;
• L is —(CH2)q— or —(CH2)q′O— where q is 0, 1, 2 or 3 and q′ is 2 or 3;
• J is
• (i) a group —CR5═CR6— where R5 and R6 are independently hydrogen or C1-6alkyl;
• or
• (ii) a group —CHR7—CHR8— where R7 and R8 are independently hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, heteroaryl, a group —NHCOR9— or —NHSO2R9— in which R9 is as defined above or a group —(CH2)1-6NRxRy— in which Rx and Ry are as defined above;
• or
• (iii) a single bond;
• or
• (iv) —CHR6— where R6 is as defined above;
• or
• (v) a group —O—CHR10—, —NR11—CH7R10— or —CR12R13—CHR10— where R10 and R11 are independently hydrogen or C1-6alkyl and R12 and R13 are independently C1-6alkyl or R12 and R13 combine together to form a C3-7 cycloalkyl or a 5-7 membered heterocyclic ring;
• m, n and p are independently 0, 1, 2 or 3;
• and
• t is 0, 1 or 2.

A process for the preparation of a compound of formula (I) which comprises hydrolysis of a carboxylic acid ester derivative of formula (II):

• wherein
• A and B are independently aryl or heteroaryl;
• Q is C, CH or together with the group V or group D forms a 5-7 membered heterocyclic ring;
• D is hydrogen, C1-6alkyl or together with the group Q forms a 5-7 membered heterocyclic ring;
• R1, R2 and R3 are independently C1-6alkyl, halogen, C1-6alkoxy, hydroxy, cyano, CF3, nitro, C1-6alkylthio, amino, mono- or di-C1-6alkylamino, carboxy, C1-6alkanoyl, amido, mono- or di-C1-6alkylamido, NHCOR9 or NHSO2R9 in which R9 is C1-6alkyl, C3-7cycloalkyl or phenyl (optionally substituted by up to three groups selected from C1-6alkyl, halogen, C1-6alkoxy, cyano, phenyl or CF3) or is a group -E-(CH2)1-6NRxRy in which B is a single bond or —OCH2— and Rx and Ry are independently hydrogen, C1-6alkyl or combine together to form a 5-7 membered heterocyclic ring;
• R4 is hydrogen, C1-6alkyl, halogen or C1-6alkoxy;
• V is O, S, NH, N—C1-6alkyl, NNO2, NCN or together with the group Q forms a 5-7 membered heterocyclic ring;
• W, X, Y and Z are independently C, CH or CH2;
• represents a single or double bond;
• L is —(CH2)q— or —(CH2)q′O— where q is 0, 1, 2 or 3 and q′ is 2 or 3;
• J is
• (i) a group —CR5═CR6— where R5 and R6 are independently hydrogen or C1-6alkyl;
• or
• (ii) a group —CHR7—CHR8— where R7 and R8 are independently hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, heteroaryl, a group —NHCOR9— or —NHSO2R9— in which R9 is as defined above or a group —(CH2)1-6NRxRy— in which Rx and Ry are as defined above;
• or
• (iii) a single bond;
• or
• (iv) —CHR6— where R6 is as defined above;
• or
• (v) a group —O—CHR10—, —NR11—CH7R10— or —CR12R13—CHR10— where R10 and R11 are independently hydrogen or C1-6alkyl and R12 and R13 are independently C1-6alkyl or R12 and R13 combine together to form a C3-7 cycloalkyl or a 5-7 membered heterocyclic ring;
• m, n and p are independently 0, 1, 2 or 3;
• and
• t is 0, 1 or 2;
• and R is a group capable of forming a carboxylic acid ester and optionally thereafter forming a carboxylic acid ester or a pharmaceutically acceptable salt thereof.