Compounds

A compound of formula (I) or a pharmaceutically acceptable salt thereof:

• in which:
• R1, R2 and R3 are independently hydrogen, halogen, cyano, CF3, or C1-6 alkyl;
• R4is
• halogen, CO2R12,
• C1-6 alkoxy where the alkyl group may form a 3-6 membered saturated ring or may be substituted with 1-3 fluorine atoms or a cyano group;
• C3-6 alkenyloxy or C3-6 alkynyloxy where either may be optionally substituted with hydroxy or NR14R15;
• OC1-6 alkyl-X—C1-6 alkyl where the alkyl groups may form a 3-6 membered saturated ring;
• OC1-6 alkylR11, or OC2-6 alkyl-X—R11 where the alkyl group may form a 3-6 membered saturated ring and is optionally substituted with 1-3 groups selected from hydroxy, halogen, NR14R15, SR13, S(O)2R13, S(O)13;
• OC1-6 alkylR16;
• R5 and R6 are independently
• hydrogen, cyano, halogen, CO2R12, CONR14R15;
• C1-6 alkyl optionally substituted by hydroxy, NR14R15, or 1-3 fluorines;
• C1-6 alkylR11 or XCH(R11)C1-6 alkyl or XCH(R16)C1-6 alkyl where the alkyl group may be optionally substituted with 1-3 groups selected from hydroxy, and NR14R15;
• NR14R15;
• N(R11)R11;
• X—(CH2)qNR14R15;
• (CH2)nNR14R15;
• C3-6 alkynyl or C3-6 alkenyl optionally branched and optionally substituted with 1-3 groups selected from hydroxy, cyano, halogen and ═O;
• R11;
• X—R11;
• X—R12;
• X—C1-6alkylR16;X—R16;
• X—(CH2)nCO2R12;
• X—(CH2)nCONR14R15;
• X—(CH2)nR11;
• X—(CH2)nCN;
• X—(CH2)qOR12;
• (CH2)nOR12;
• (CH2)n-X—R11;
• X—(CH2)qNHC(O)NHR12;
• X—(CH2)qNHC(O)R12;
• X—(CH2)qNHS(O)2R12;
• X—(CH2)qNHS(O)2R11;
• X—C3-6 alkenyl;
• X—C3-6 alkynyl;
• n is 1 ,2, 3, 4 or 5;
• q is 2, 3, 4, 5 or 6;
• X is NR13, O, S, S(O), S(O)2;
• R11 is
• an aryl group or a 5-7 membered heteraromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur each of which can be optionally substituted by 1-3 groups selected from halogen, C(O)NR14R15, C(O)OR12, hydroxy, ═O,═S, CN, NO2,
• NR14R15, X(CH2)qNR14R15, (CH2)nNR14R15, (CH2)nOH, SR13, S(O)R13, S(O)2R13 C1-6 alkyl-X—C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy where the alkyl group may form a 3-6 membered ring or is optionally substituted with 1-3 groups selected from hydroxy, halogen, NR14R15, SR13, S(O)R13, S(O)2R13;
• R12 and R13 are independently hydrogen or C1-6 alkyl where the alkyl group may be substituted with 1-3 fluorine atoms or may form a saturated 3-6 membered ring;
• R14 and R15 are independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl or (CH2)qOH, or R14 and R15 together with the nitrogen atom to which they are attached form a 4-8 membered saturated ring containing 1-3 heteroatoms selected from nitrogen, oxygen and sulphur and optionally substituted by C1-6 alkyl, C1-6 alkyl-OH, or hydroxy;
• and
• R16 is a 4-8 membered saturated ring containing 1-3 heteroatoms selected from nitrogen, oxygen or sulphur and optionally substituted with 1-3 groups selected from hydroxy, cyano, halogen and ═O.