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US 7,410,964 B2Granted
Cyclohexyl sulphones as gamma-secretase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsKevin Dinnell, Karl Richard Gibson, Timothy Harrison, Richard Alexander Jelley, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Brian John Williams
Life of this patent
Estimating the term…
Abstract
Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
Claims4
A compound according to one of the following formulae:
- wherein
- R1 represents H or C1-4alkyl;
- R2 and R4 independently represent H or a hydrocarbon group of up to 10 carbon atoms, optionally substituted with CF3, CHF2, halogen, CN, OR5, COR5, CO2R5, OCOR6, N(R5)2, CON(R5)2 or NR5COR6;
- R5 represents H or C1-4alkyl;
- R6 represents C1-4alkyl;
- and
- Ar1 and Ar2 independently represent phenyl or heteroaryl, either of which bears 0-3 substituents independently selected from halogen, CN, NO2, CF3, CHF2, OH, OCF3, CHO, CH═NOH, C1-4alkoxy, C1-4alkoxycarbonyl, C2-6acyl, C2-6alkenyl and C1-4alkyl which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH and C1-4alkoxy;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.