Adenovirus serotype 30 (Ad30)
AssigneeUniversity of Iowa Research Foundation
InventorsBeverly L. Davidson, Lane K. Law
Life of this patent
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Abstract
The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and viral particles and cells containing such expression vectors. The present invention further provides methods of treating genetic diseases or cancers in a mammal using the polynucleotides, polypeptides, expression vectors, viral particles and cells of the present invention.
Claims17
A method of transducing a cell lacking coxsackievirus and adenovirus receptor (CAR) comprising contacting the cell with an expression vector comprising an Ad backbone nucleic acid sequence and polynucleotide encoding a chimeric adenovirus (Ad) fiber polypeptide comprising at least one of the following:
- a tail region, a shaft region and a knob region, wherein the polynucleotide encoding a chimeric Ad fiber polypeptide encodes SEQ ID NO:1, encodes amino acids 46-188 of SEQ ID NO:1, encodes amino acids 189-371 of SEQ ID NO:1, or wherein the polynucleotide comprises SEQ ID NO:12, comprises nucleotides 1-564 of SEQ ID NO:12, comprises nucleotides 1-135 of SEQ ID NO:12, or comprises nucleotides 136-564 of SEQ ID NO:12.
Dependencies are inferred from the claim text.