Peptides of CaV2.2 that inhibit pain
AssigneeBoard of Regents, The University of Texas System
InventorsMary Garry, Ilya Bezprozvanny
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Abstract
The present invention relates to peptides of CaV2.2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2.2. and is believed to inhibit the interaction of CaV2.2 with Mint1-PDZ1. The invention is related to use of this peptide to treat pain and to use of this peptide in binding reaction with int-PDZ to screen for small molecules that can inhibit pain.
Claims12
An isolated and purified peptide of 4 to 12 residues comprising the sequence DHWC (SEQ ID NO:1).
A method of treating pain in an animal comprising administering to said animal a peptide of 4 to 12 residues comprising the sequence DHWC (SEQ ID NO:I) said peptide dispersed in a pharmaceutically acceptable buffer, diluent or excipient.
Dependencies are inferred from the claim text.