Treatment of inflammatory bowel disease
AssigneeThe University of Queensland
InventorsTrent Martin Woodruff, Stephen Maxwell Taylor, David Fairlie
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Abstract
This invention relates to methods of treatment of inflammatory bowel disease, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the methods of the invention are disclosed.
Claims9
A method of treating ulcerative colitis, comprising administering an effective amount of the compound AcPhe[Orn-Pro-D-Cyclohexylalanine-Trp-Arg] to a subject in need thereof.
A method of relieving or ameliorating the effects of ulcerative colitis, comprising administering an effective amount of the compound AcPhe[Orn-Pro-D-Cyclohexylalanine-Trp-Arg] to a subject in need thereof.
Dependencies are inferred from the claim text.