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US 7,410,943 B2Granted
Imaging agents
AssigneeGe Healthcare Limited
InventorsAlan Cuthbertson, Magne Solbakken
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
Claims13
A compound of formula (I):
- wherein
- R2 is
- wherein b is an integer of from 0 to 10;
- R3 is a C1-4 alkylene or C2-4 alkenylene bridge;
- W1 is absent or represents a spacer moiety which is a C1-30 hydrocarbyl group optionally including 1 to 10 heteroatoms selected from oxygen, nitrogen, and sulphur, and is preferentially derived from glutaric and/or succinic acid and/or a polyethyleneglycol based unit and/or a unit of Formula:
- Z1 is an antineoplastic agent, a chelating agent or a reporter moiety.
3 more elements
A compound of formula (Ia):
- wherein
- R1 is either a bond or is
- wherein a is an integer of from 1 to 30;
- R2 is
- wherein b is an integer of from 0 to 10;
- R3 is a C1-4 alkylene or C2-4 alkenylene bridge;
- the Linker is a C1-30 hydrocarbyl group optionally including 1 to 10 heteroatoms.
4 more elements
Dependencies are inferred from the claim text.