Method for monitoring collagen type II degradation in cartilage
AssigneeUniversite De Liege
InventorsJean-Yves Reginster, Michelle Deberg, Yves Henrotin, Stephan Christgau
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Abstract
A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II.
Claims9
A method of qualitative or quantitative assay of unwound collagen type II fragments containing amino acid sequence HRGYPGLDG (SEQ ID NO:
- 1) in a biological sample comprising
- contacting the fragments with an antibody that binds with an epitope in the amino acid sequence HRGYPGLDG (SEQ ID NO:
- 1) and
- detecting resulting immunoreaction.
Dependencies are inferred from the claim text.