Methods and compositions relating to HPV-associated pre-cancerous and cancerous growths, including CIN
AssigneeBoard of Regents, The University of Texas System
InventorsJagannadha K. Sastry, Guillermo Tortolero-Luna, Michele Follen
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Abstract
The present invention concerns the use of E6 and/or E7 peptides from human papilloma virus (HPV) to evaluate a cell-mediated response in a patient infected with HPV to determine the prognosis for that patient with respect to the development or recurrence of pre-cancerous or cancerous growths, including cervical intraepithelial neoplasia (CIN).
Claims40
A method for determining the possibility of recurrence of a pre-cancerous or cancerous growth in a patient infected with human papilloma virus (HPV) or suspected of being infected with HPV, wherein the patient also has or had a pre-cancerous or cancerous growth on or around the cervix comprising determining whether the patient exhibits a cell-mediated response to at least one E6 or E7 peptide of HPV, wherein a cell-mediated response to such at least one peptide is indicative of a reduced risk of such a recurrence.
Dependencies are inferred from the claim text.