Controlled release and taste masking oral pharmaceutical composition
AssigneeCosmo Technologies Limited
InventorsRoberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
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Abstract
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Claims11
A controlled release oral pharmaceutical composition containing budesonide as active ingredient consisting essentially of:
- a) a lipophilic matrix consisting of lipophilic compounds with a melting point between 40° C. and 90 C. in which the active ingredient is at least partially inglobated;
- b) an amphiphilic matrix;
- c) an outer hydrophilic matrix consisting of hydrogel forming compounds in which the lipophilic matrix and the amphiphilic matrix are dispersed, wherein the combination of the matrices from a), b), and c) provides controlled release.
Dependencies are inferred from the claim text.