Materials and methods relating to fusion proteins for inducing an immune response
AssigneeCancer Research Technology Limited
InventorsNatalia Savelyeva, Freda Stevenson
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Abstract
A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein, said fusion protein comprising said antigen and an adjuvant sequence derived from a plant viral coat protein. Methods for making constructs and methods of using such constructs for the treatment of infectious disease, cancer and B cell malignancy, are provided.
Claims23
A nucleic acid construct suitable for administration to a subject comprising a nucleotide sequence encoding a fusion protein comprising an antigen and Potato Virus X Coat Protein (PVXCP);
- wherein said nucleic acid construct directs expression of said fusion protein and induces expression of an immune response to said antigen in said subject.
A method of making a nucleic acid construct which induces an immune response against an antigen comprising:
- cloning a nucleotide sequence encoding said antigen;
- and
- introducing the cloned nucleotide sequence into a vector, said vector directing expression of the antigen as a fusion with an adjuvant, wherein said adjuvant is PVXCP.
Dependencies are inferred from the claim text.