Tissue metabolic stress monitoring
AssigneeRockland Technimed Ltd.
InventorsPradeep M. Gupte, Robert Louis Delapaz
Life of this patent
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Abstract
Various pathophysiological states are determined by evaluating the rate of 17O-containing water production oxygen using proton MRI. The method can be used to identify viable but threatened myocardium, injured by viable muscle, penumbra tissue in a stroke patient, and the like.
Claims16
A method of differentiating zones in ischemic tissue by measuring an oxygen extraction fraction in the ischemic tissue by means of a proton magnetic resonance imaging system, the method comprising:
- administering an effective imaging amount of a diagnostic imaging agent, the diagnostic imaging agent comprising 17O2 and a biologically acceptable carrier, wherein said diagnostic imaging agent has an ionic composition essentially equal to that of blood and an average particle size of less than about 0.6 microns;
- and
- determining a risk of tissue damage by comparing a first oxygen extraction fraction of a first tissue zone in the ischemic tissue to a second oxygen extraction fraction of a second tissue zone in the ischemic tissue using the proton magnetic resonance imaging system.
A method of determining penumbra brain tissue in a stroke patient by measuring an oxygen extraction fraction in the brain by means of a proton magnetic resonance imaging system, the method comprising:
- administering an effective imaging amount of a diagnostic imaging agent, the diagnostic imaging agent comprising a complex of 17O2 and a biologically acceptable liquid carrier, wherein said complex has an ionic composition essentially equal to that of blood and an average particle size of less than about 0.6 microns;
- and
- identifying tissue under oxidative stress, said identifying comprising comparing an oxygen extraction fraction from a first tissue zone in the penumbra to an oxygen extraction fraction of a second tissue zone in the penumbra using a proton magnetic resonance imaging system.
Dependencies are inferred from the claim text.