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US 7,408,095 B2Granted
Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen
AssigneePhylonix Pharmaceuticals, Inc.
InventorsGeorge N. Serbedzija, Patricia McGrath
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Abstract
Methods of introducing heterologous cells into fish are provided. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are also useful, for example, for diagnosing the presence of small quantities of cancerous cells or pathogens in patient tissue samples.
Claims15
A method of analyzing a sample for presence of a cancer cell or pathogen, comprising:
- (a) obtaining a sample from a patient containing a cell or population of cells;
- (b) introducing the cell or the population of cells into a zebrafish embryo that has not yet developed an immune system that would subject the cell or population of cells to immune rejection;
- and
- (c) detecting a property of the cell or the population of cells to indicate whether the cell or the population of cells comprises a cancer cell or pathogen.
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Dependencies are inferred from the claim text.