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US 7,408,082 B1Granted
Racemisation process
AssigneeNPIL Pharmaceuticals (UK) Limited
InventorJohn Blacker
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Abstract
The present invention relates to a novel process for obtaining (1S,4S)N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine from a mixture of its isomers. The process involves isomerising the 1-position and the 4-position and effecting separation of the desired isomer by methods such as fractured crystallization. The process can be operated as a continuous process.
Claims20
A process for isomerising the C-1 position of N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine using a transition metal catalyst and optionally a promoter.
Dependencies are inferred from the claim text.