Anthranilic acid derivatives useful in treating infection with hepatitis C virus
AssigneesWyeth, ViroPharma Incorporated
InventorsJonathan D. Bloom, Thomas R. Bailey
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Abstract
The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.
Claims12
A method of treating hepatitis C in a mammal having symptoms of hepatitis C comprising administering to said mammal an effective amount of a pharmaceutical composition comprising a compound having the structure
- and pharmaceutically acceptable salts thereof, wherein:
- R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, methyl, ethyl, methoxy, nitro, C2-C4 alkenyl, cyano, and trifluoromethyl;
- X is O, S, NH, or NR where R is a C1-C4 alkyl group;
- W is CO2H or 5-tetrazolyl;
- Z is hydrogen or mono-methyl and
- G is either OH, F, or hydrogen.
A method of treating hepatitis C in a mammal having symptoms of hepatitis C comprising administering to said mammal an effective amount of a pharmaceutical composition comprising a compound having the structure
- and pharmaceutically acceptable salts thereof, wherein:
- R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, methyl, ethyl, methoxy, nitro, C2-C4 alkenyl, cyano, and trifluoromethyl;
- X is O, S, NH, or NR where R is a C1-C4 alkyl group;
- Y is CO2H or CO2CH3;
- Z is hydrogen or mono-methyl;
- G1 is OH, F, methoxy or hydrogen;
- and
- G2 is either OH, Cl, methoxy or hydrogen.
Dependencies are inferred from the claim text.