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US 7,408,045 B2Granted
Adsorbent of high-mobility-group protein and body fluid-purification column
AssigneeToray Industries, Inc.
InventorsIkuro Maruyama, Nobuo Ida, Sanae Masuko
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Abstract
An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group(s) and/or (a) hydrophobic functional group(s) is(are) immobilized.
Claims22
A method for adsorbing high-mobility-group proteins in body fluid, comprising:
- contacting an adsorbent with body fluid so as to adsorb said high-mobility-group proteins in said body fluid to said adsorbent;
- wherein said adsorbent comprises a water-insoluble carrier on which a substance(s) having a hydrogen-bondable functional group(s) and/or a hydrophobic functional group is(are) immobilized, and
- wherein said adsorbent has a rate of adsorption for high-mobility-group proteins of not less than 50%, and has a rate of adsorption for serum albumin of not more than 20% and wherein said body fluid is blood.
Dependencies are inferred from the claim text.