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US 7,408,031 B2Granted
Peptide epitopes recognized by disease promoting CD4+ T lymphocytes
AssigneesMGI PHARMA Biologics, Inc., King's College London
InventorsMark Peakman, Roman M. Chicz
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Abstract
The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.
Claims7
An isolated peptide that is less than 26 amino acid residues in length and binds to HLA-DR4, comprising a sequence AYQAEPNT (SEQ lID NO:49).
Dependencies are inferred from the claim text.